While using it, Much of the pressure on my hand is right where the bone of the base of the finger is.

If it were wider, and not as tall but still held the same wrist angle I could grip it easier. I have to hold it in an unnatural way to use it. I don't feel confident when holding it and often will click stuff by accident. It's very tall in the palm of the hand and somewhat awkward to hold because of that. There is a rubber pad to rest your thumb which helps grip the mouse when moving it around. I found vertical mouse/mice painful to hold. The wrist angle is not as aggressive as a vertical mouse but it's a nice compromise and I definitely notice less fatigue after a long day with this mouse. It has a good feel to it no ratchet mechanism relies on some friction is made of solid metal There's a dedicated scroll wheel for panning left to right across the page. There's an internal rechargeable battery that lasts a very long time and charging can be accomplished at USB-C charging rates. The mouse wheel saves enough time scrolling to justify its high price point. There's a button right next to the mouse wheel to disable/enable the ratchet function. The mouse wheel is solid metal, heavy, and seems to spin forever, just like a fidget spinner. Saves time, is good for small to medium sized hands, great features, well built, ergonomics very close to perfect

Logitech mouse mac gestures